Megazol and its bioisostere 4H-1,2,4-triazole: comparing the trypanocidal, cytotoxic and genotoxic activities and their in vitro and in silico interactions with the Trypanosoma brucei nitroreductase enzyme

Megazol (7) is a 5-nitroimidazole that is highly active against Trypanosoma cruzi and Trypanosoma brucei, as Cereal well as drug-resistant forms of trypanosomiasis.Compound 7 is not used clinically due to its mutagenic and genotoxic properties, but has been largely used as a lead compound.Here, we compared the activity of 7 with its 4H-1,2,4-triazo

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Eating epilepsy. A narrative review

Eating epilepsy (EE) is rare reflex epilepsy Cosmetics in which seizures are triggered by mechanisms related to the eating process.In this narrative review, we analyzed case series and case reports found in the literature and describe sociodemographic, semiological, and radiological characteristics of patients with EE in the general population.Our

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